PlaToLoCo - a new meta-server for LCR analysis
May 19, 2020PlaToLoCo: the first web meta-server for visualization and annotation of low complexity regions in proteins.
Jarnot P, Ziemska-Legiecka J, Dobson L, Merski M, Mier
P, Andrade-Navarro MA, Hancock JM, Dosztanyi Z, Paladin L, Necci M,
Piovesan D, Tosatto SCE, Promponas VJ, Grynberg M, Gruca A.
Nucleic Acids Research (Web Server issue 2020),
gkaa339 https://doi.org/10.1093/nar/gkaa339
Low complexity regions (LCRs) in protein sequences show bias in amino acid composition compared to typically observed
sequence diversity. LCRs may co-occur
with intrinsically disordered regions, are highly conserved in many
organisms, and often play important roles in protein functions and in
diseases. PlaToLoCo -
PLAtform of TOols for LOw COmplexity - is a meta-server that integrates and
collects the output of five different state-of-the-art tools for
discovering LCRs and provides functional annotations such as domain
detection, transmembrane segment prediction, and calculation of amino
acid frequencies. In addition, the union or intersection of the results
of the search on a query sequence can be obtained to aid the interpretation of the results.
Matthew Merski contributed to the collaborative effort behind the project, and his work was supported by funding from the National Science Centre, Poland (#2014/15/D/NZ1/00968).
The PlaToLoCo
platform is available at: http://platoloco.aei.polsl.pl/
