Maria Górna, Ph.D.
Head of the Structural Biology Group
I graduated from the interdisciplinary MISMaP programme at the University of Warsaw, combining biotechnology and chemistry. Next, I trained in structural biology during PhD studies at the University of Cambridge and a short research stay at SGC at the University of Oxford. Over the course of my postdoctoral work at CeMM in Vienna, I collaborated with systems, chemical and computational biologists and medical geneticists on a number of projects related to innate immunity, leukemia and some rare genetic conditions. In 2015, I returned to structural biology and Poland to help establish a protein crystallography laboratory at the newly opened BCRC and our Department of Chemistry. Since then, I visited USA and UK for short sabbaticals/training in cryoEM and membrane protein crystallography as a Fulbright and EMBO fellow. I established the Go!RNA Structural Biology Group which leads both applied and basic research projects thanks to funding from multiple international and national funding bodies. I also helped establish our Crystallography and Biophysics Core Facility, as well as served as an expert for industry and on the MCAA Board.
My
broad interest is in using three-dimensional structural models to explain
protein function: e.g. the molecular mechanisms in RNA metabolism from
viruses or bacteria to humans, or identifying the role of mutations
underlying human diseases. I have also developed a passion for trying
to translate my research findings into useful inventions through drug development or protein
engineering and repurposing.
Research positions and degrees
Current positions:
Since 2016 Leader of the Structural Biology Group, Biological and Chemical Research Centre, University of Warsaw;
Since 2015 Assistant Professor (Adiunkt), Department of Chemistry, University of Warsaw;
Past research experience:
10.2018-03.2021 Expert, WPD Pharmaceuticals, Warsaw, Poland
01-02.2020 Fulbright Visiting Scholar, Jean-Paul Armache laboratory, Eberly College of Science, Pennsylvania State University, USA
05-07.2015 Visiting researcher (EMBO ASTF), Membrane Protein Laboratory, Diamond Light Source, Harwell Science & Innovation Campus, UK
2010-2015 Postdoctoral Fellow, Giulio Superti-Furga group, CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria
04-05.2010 Visiting collaborator, Stefan Knapp group, Structural Genomics Consortium, University of Oxford, UK
Education and degrees:
2006-2010 PhD student in Biochemistry and Marie-Curie Early Stage Researcher (EU FP6), Ben Luisi group, Department of Biochemistry, University of Cambridge, UK;
2002-2006 Master's in Biotechnology (and Theoretical Chemistry), College of Inter-faculty Individual Studies in Mathematics and Natural Sciences (MISMaP), University of Warsaw, Poland;
2004/2005 Socrates-Erasmus exchange student, Georg-August Universitaet, Goettingen, Germany;
2001-2004 Bachelor in Biotechnology, Faculty of Biology, University of Warsaw;
1997-2001 Experimental mathematics class (Matex A) , XIV Liceum im. Staszica, Warsaw
Awards & grants
2023, Rector's Distinction for scientific achievements, University of Warsaw
2023, Rector's Award for scientific achievements (individual, III degree), Department of Chemistry, University of Warsaw
2023, WEAVE UNISONO grant, National Science Centre, Poland
2022, OPUS 21 grant, National Science Centre, Poland
2021, listed by Kobiety Forbes Women 2021 among the top 100 inspiring women in Poland
2021, L’Oréal-UNESCO For Women in Science scholarship award 2020, L’Oréal Poland
2019, Fulbright STEM Impact Award, Polish-U.S. Fulbright Commission
2018, FIRST TEAM 5/2018 grant, Foundation for Polish Science
2017, Fellowship for outstanding young scientists, Ministry of Science and Higher Education, Poland, #0707/E-343/STYP/12/2017
2015, EMBO Installation Grant
2015, LIDER VI grant, National Centre for Research and Development, Poland
2015, SONATA 8 grant, National Science Centre, Poland
2015, Marie Skłodowska-Curie Actions Individual Fellowship, H2020
2015, 2016 Grant for young researchers (DSM), University of Warsaw
2015, EMBO Advanced Short-Term Fellowship, #235-2015
2015, FEBS Journal Poster Prize, Conference "Multi-Pole Approach to Structural Science", Warsaw, PL
2009, Clare Hall Bursary, University of Cambridge, UK
2009, General Travel Grant and publication of a Traveller's Tale, The Biochemical Society, UK
2008, Qiagen Poster Prize, Department of Biochemistry, University of Cambridge, UK
2006, Cambridge European Trust Honorary Scholar
2006, Marie Curie Host Fellowship for Early Stage Researchers within ChemBioCam RTN (EU FP6), Department of Biochemistry, University of Cambridge, UK
2006, BBSRC PhD studentship (declined in favour of the above)
2004, 2005, 2006 (annually), Studentship of the Polish Minister of Science/Education for outstanding achievements in study
Other selected activities
Since 2023, Associate Editor of the European Review (published by Cambridge University Press on behalf of Academia Europaea)
2022, 2023 TopMinds Mentor, Top 500 Innovators/Polish-U.S. Fulbright Commission
2021 - 2028 Member of the Young Academy of Europe
2021 - 2024 Member of the University of Warsaw Scientific Council for Biological Sciences
2018 - 2020 Board Member, Marie Curie Alumni Association, EC-funded non-profit
2016, Founding Chair of the Polish Chapter of the Marie Curie Alumni Association
2009, Participation in the 4th SciFoo coorganized by Nature, Google and O'Reilly Media, at Googleplex, Mountain View, CA, USA
2005/2006, President of the Student Society of Genetics and Epigenetics (KNGiE), Faculty of Biology, University of Warsaw (2003/2004, co-founder and vice-president)
Since 2020, Remote Evaluator, European Commission expert number: EX2015D236921
Since 2020, Collaboration on behalf of the MCAA Policy Working Group and EMBO with the Initiative for Science in Europe (ISE), e.g. contribution to discussions about Horizon 2020, Widening Countries, ISE position papers on Horizon Europe (2021) (2023), ISE recommendations towards FP10 (2023) - member of the Horizon Europe Working Group
Publication metrics on Scopus
Maria Górna – publication list
- 2023 A unique mRNA decapping complex in trypanosomes. Nucleic Acids Res 51147520-7540
- 2023 Targeted Protein Degradation Might Present a Novel Therapeutic Approach in the Fight Against African Trypanosomiasis. Eur J Pharm Sci 186106451
- 2023 MultiOMICs landscape of SARS-CoV-2-induced host responses in human lung epithelial cells. iScience 261105895
- 2023 β-Sitosterol could serve as a dual inhibitor of Trypanosoma congolense sialidase and phospholipase A2: in vitro kinetic analyses and molecular dynamic simulations. Mol Divers 2741645-1660
- 2022 The Role of Electrostatic Interactions in IFIT5-RNA Complexes Predicted by the UBDB+EPMM Method. J Phys Chem B 126459152-9167
- 2022 A cap 0-dependent mRNA capture method to analyze the yeast transcriptome. Nucleic Acids Res 5022e132
- 2022 Immunoinformatic design of a putative multi-epitope vaccine candidate against Trypanosoma brucei gambiense. Comput Struct Biotechnol J 205574-5585
- 2022 The Repeating, Modular Architecture of the HtrA Proteases. Biomolecules 126793
- 2021 A Uniform Benchmark for Testing SsrA-Derived Degrons in the Escherichia coli ClpXP Degradation Pathway. Molecules 26195936
- 2021 The Effect of Mutations in the TPR and Ankyrin Families of Alpha Solenoid Repeat Proteins Front Bioinform 1696368
- 2021 Applications of Bacterial Degrons and Degraders - Toward Targeted Protein Degradation in Bacteria. Front Mol Biosci 8669762
- 2021 A Simple Model for the Total Number of SARS-CoV-2 Infections on a National Level. Epidemiol Infect 149e80
- 2020 The PI3K pathway preserves metabolic health through MARCO-dependent lipid uptake by adipose tissue macrophages. Nat Metab 2121427-1442
- 2020 A Geometric Definition of Short to Medium Range Hydrogen-Mediated Interactions in Proteins. Molecules 25225326
- 2020 Self-analysis of repeat proteins reveals evolutionarily conserved patterns. BMC Bioinformatics 211179
- 2018 Structural, biochemical, and evolutionary characterization of glyoxylate/hydroxypyruvate reductases shows their division into two distinct subfamilies. Biochemistry 576963-977
- 2017 NDEL1-PDGFRB fusion gene in a myeloid malignancy with eosinophilia associated with resistance to tyrosine kinase inhibitors. Leukemia 311237-240
- 2015 Mutations in LONP1, a mitochondrial matrix protease, cause CODAS syndrome. Am J Med Genet A 16771501-9
- 2014 The SH2 domain regulates c-Abl kinase activation by a cyclin-like mechanism and remodulation of the hinge motion. PLoS Comput Biol 1010e1003863
- 2014 MMP13 mutations are the cause of recessive metaphyseal dysplasia, Spahr type. Am J Med Genet A 164A51175-9
- 2014 IFITs: Emerging Roles as Key Anti-Viral Proteins. Front Immunol 594
- 2013 FAM111A mutations result in hypoparathyroidism and impaired skeletal development. Am J Hum Genet 926990-5
- 2013 Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins. Nature 494743560-4
- 2012 The seed region of a small RNA drives the controlled destruction of the target mRNA by the endoribonuclease RNase E. Mol Cell 476943-53
- 2012 From conformational chaos to robust regulation: the structure and function of the multi-enzyme RNA degradosome. Q Rev Biophys 452105-45
- 2011 IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA. Nat Immunol 127624-30
- 2011 Functional dissection of the TBK1 molecular network. PLoS One 69e23971
- 2010 The regulatory protein RraA modulates RNA-binding and helicase activities of the E. coli RNA degradosome. RNA 163553-62
- 2008 Reconstitution and analysis of the multienzyme Escherichia coli RNA degradosome. J Mol Biol 3824870-83
- 2007 Design and chance in the self-assembly of macromolecules. Biochem Soc Trans 35Pt 3502-7
#Equal contribution