patent applications
Górna M, Nowacka M, Izert M, Kowalska M, Karolak N, Klimecka M, Młynarczyk K. Sposób selekcji i/lub wzbogacania RNA, cząsteczka RNA oraz jej zastosowanie (A method of RNA selection and/or enrichment, a RNA molecule and use thereof). P.430151 (05.06.2019), PCT/IB2020/055263 (04.06.2020) WO/2020/245755, US17616459 (03.12.2021), EP20743765.8 (04.01.2022)
Górna M, Izert M, Klimecka M, Szybowska P, Antosiewicz A,
Twardowski P. Konstrukty peptydowe do celowanej degradacji białek (Peptide constructs for targeted protein degradation). P.439032 (24.09.2021), PCT/IB2022/059128 (26.09.2022) WO/2023/047376
PREPRINTS
Merski M, Górna MW. Thiamin-Diphosphate Enzymes Are an Ancient Family of Repeat Proteins. DOI: 10.1101/2021.03.21.436335
IN PRESS
Go!RNA lab publications
- 2023 A unique mRNA decapping complex in trypanosomes. Nucleic Acids Res 51147520-7540
- 2023 Targeted Protein Degradation Might Present a Novel Therapeutic Approach in the Fight Against African Trypanosomiasis. Eur J Pharm Sci 186106451
- 2023 MultiOMICs landscape of SARS-CoV-2-induced host responses in human lung epithelial cells. iScience 261105895
- 2023 β-Sitosterol could serve as a dual inhibitor of Trypanosoma congolense sialidase and phospholipase A2: in vitro kinetic analyses and molecular dynamic simulations. Mol Divers 2741645-1660
- 2022 The Role of Electrostatic Interactions in IFIT5-RNA Complexes Predicted by the UBDB+EPMM Method. J Phys Chem B 126459152-9167
- 2022 A cap 0-dependent mRNA capture method to analyze the yeast transcriptome. Nucleic Acids Res 5022e132
- 2022 Immunoinformatic design of a putative multi-epitope vaccine candidate against Trypanosoma brucei gambiense. Comput Struct Biotechnol J 205574-5585
- 2022 The Repeating, Modular Architecture of the HtrA Proteases. Biomolecules 126793
- 2022 Bacterial RNA chaperones and chaperone-like riboregulators: behind the scenes of RNA-mediated regulation of cellular metabolism. RNA Biol 191419-436
- 2021 A Uniform Benchmark for Testing SsrA-Derived Degrons in the Escherichia coli ClpXP Degradation Pathway. Molecules 26195936
- 2021 The Effect of Mutations in the TPR and Ankyrin Families of Alpha Solenoid Repeat Proteins Front Bioinform 1696368
- 2021 Applications of Bacterial Degrons and Degraders - Toward Targeted Protein Degradation in Bacteria. Front Mol Biosci 8669762
- 2021 A Simple Model for the Total Number of SARS-CoV-2 Infections on a National Level. Epidemiol Infect 149e80
- 2020 The PI3K pathway preserves metabolic health through MARCO-dependent lipid uptake by adipose tissue macrophages. Nat Metab 2121427-1442
- 2020 A Geometric Definition of Short to Medium Range Hydrogen-Mediated Interactions in Proteins. Molecules 25225326
- 2020 PlaToLoCo: the first web meta-server for visualization and annotation of low complexity regions in proteins. Nucleic Acids Res 48W1W77–84
- 2020 Self-analysis of repeat proteins reveals evolutionarily conserved patterns. BMC Bioinformatics 211179
- 2018 Structural, Biochemical, and Evolutionary Characterizations of Glyoxylate/Hydroxypyruvate Reductases Show Their Division into Two Distinct Subfamilies. Biochemistry 576963-977
#Equal contribution
DEPOSITIONS
Small molecule crystal structures
Malinska M, Gorna M, Merski M (2019). Zn-TCEP metal-organic salt = [Zn(H2O)5][Zn2C18H24O12P2]·7H2O
catena-[Penta-aqua-zinc(ii) bis(μ-3,3',3''-phosphinetriyltripropionato)-di-zinc(ii) heptahydrate]
CCDC ICSD entry 1964322 | CSD entry DEHFUR01 | doi:10.5517/ccdc.csd.cc23y17c
RNA sequencing data
A cap-dependent mRNA capture method to analyze the transcriptome (2022) ENA: PRJEB49214 | GEO: GSE210198.
Mass spectrometry data
PRIDE
Maria Górna – publication list
- 2023 A unique mRNA decapping complex in trypanosomes. Nucleic Acids Res 51147520-7540
- 2023 Targeted Protein Degradation Might Present a Novel Therapeutic Approach in the Fight Against African Trypanosomiasis. Eur J Pharm Sci 186106451
- 2023 MultiOMICs landscape of SARS-CoV-2-induced host responses in human lung epithelial cells. iScience 261105895
- 2023 β-Sitosterol could serve as a dual inhibitor of Trypanosoma congolense sialidase and phospholipase A2: in vitro kinetic analyses and molecular dynamic simulations. Mol Divers 2741645-1660
- 2022 The Role of Electrostatic Interactions in IFIT5-RNA Complexes Predicted by the UBDB+EPMM Method. J Phys Chem B 126459152-9167
- 2022 A cap 0-dependent mRNA capture method to analyze the yeast transcriptome. Nucleic Acids Res 5022e132
- 2022 Immunoinformatic design of a putative multi-epitope vaccine candidate against Trypanosoma brucei gambiense. Comput Struct Biotechnol J 205574-5585
- 2022 The Repeating, Modular Architecture of the HtrA Proteases. Biomolecules 126793
- 2021 A Uniform Benchmark for Testing SsrA-Derived Degrons in the Escherichia coli ClpXP Degradation Pathway. Molecules 26195936
- 2021 The Effect of Mutations in the TPR and Ankyrin Families of Alpha Solenoid Repeat Proteins Front Bioinform 1696368
- 2021 Applications of Bacterial Degrons and Degraders - Toward Targeted Protein Degradation in Bacteria. Front Mol Biosci 8669762
- 2021 A Simple Model for the Total Number of SARS-CoV-2 Infections on a National Level. Epidemiol Infect 149e80
- 2020 The PI3K pathway preserves metabolic health through MARCO-dependent lipid uptake by adipose tissue macrophages. Nat Metab 2121427-1442
- 2020 A Geometric Definition of Short to Medium Range Hydrogen-Mediated Interactions in Proteins. Molecules 25225326
- 2020 Self-analysis of repeat proteins reveals evolutionarily conserved patterns. BMC Bioinformatics 211179
- 2018 Structural, biochemical, and evolutionary characterization of glyoxylate/hydroxypyruvate reductases shows their division into two distinct subfamilies. Biochemistry 576963-977
- 2017 NDEL1-PDGFRB fusion gene in a myeloid malignancy with eosinophilia associated with resistance to tyrosine kinase inhibitors. Leukemia 311237-240
- 2015 Mutations in LONP1, a mitochondrial matrix protease, cause CODAS syndrome. Am J Med Genet A 16771501-9
- 2014 The SH2 domain regulates c-Abl kinase activation by a cyclin-like mechanism and remodulation of the hinge motion. PLoS Comput Biol 1010e1003863
- 2014 MMP13 mutations are the cause of recessive metaphyseal dysplasia, Spahr type. Am J Med Genet A 164A51175-9
- 2014 IFITs: Emerging Roles as Key Anti-Viral Proteins. Front Immunol 594
- 2013 FAM111A mutations result in hypoparathyroidism and impaired skeletal development. Am J Hum Genet 926990-5
- 2013 Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins. Nature 494743560-4
- 2012 The seed region of a small RNA drives the controlled destruction of the target mRNA by the endoribonuclease RNase E. Mol Cell 476943-53
- 2012 From conformational chaos to robust regulation: the structure and function of the multi-enzyme RNA degradosome. Q Rev Biophys 452105-45
- 2011 IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA. Nat Immunol 127624-30
- 2011 Functional dissection of the TBK1 molecular network. PLoS One 69e23971
- 2010 The regulatory protein RraA modulates RNA-binding and helicase activities of the E. coli RNA degradosome. RNA 163553-62
- 2008 Reconstitution and analysis of the multienzyme Escherichia coli RNA degradosome. J Mol Biol 3824870-83
- 2007 Design and chance in the self-assembly of macromolecules. Biochem Soc Trans 35Pt 3502-7
#Equal contribution