We study the structure and function of proteins using structural biology methods such as protein crystallography and electron microscopy, bioinformatics analysis and molecular dynamics simulations, as well as by functional assays both in vitro and in cell culture.
We are especially interested in proteins for which
little structural information is available, so that we can answer vital
questions about the activity and function of these proteins. Some of our interests include proteins working on RNA, helical repeats, protein engineering and molecular diagnostics. We also use structural models of proteins to elucidate the molecular mechanisms underlying selected human diseases or to aid drug discovery. Through our findings and inventions, we would like to help combat infections or treat human inflammatory disorders.