We study the function and structure of proteins using structural biology methods such as protein crystallography and electron microscopy, advanced biochemistry, bioinformatics analysis and molecular dynamics simulations, as well as by functional assays both in vitro and in cell culture.
Some of our interests include innate immunity, RNA metabolism, infectious diseases, mitochondrial biology, protein engineering and infection diagnostics. We use structural models of proteins to elucidate the molecular mechanisms underlying selected human diseases or to aid drug discovery. We are also interested in proteins for which
little structural information is available, so that we can answer vital
questions about the activity and function of these proteins. Through our findings and inventions, we would like to help combat infections or treat human inflammatory disorders.