A review of bacterial RNA chaperones

Bacterial RNA chaperones and chaperone-like riboregulators: behind the scenes of RNA-mediated regulation of cellular metabolism

Katsuya-Gaviria K, Paris G, Dendooven T, Bandyra KJ.

RNA Biol. (2022) 19(1):419-436. doi: 10.1080/15476286.2022.2048565.

RNA chaperones ensure proper folding, stability, and ribonuclease resistance of RNA, and support the regulatory activities mediated by RNA. In bacteria, three main chaperones – Hfq, ProQ, and CsrA – have been shown to regulate numerous complex processes, including bacterial growth, stress response and virulence. In this review, Katsuya-Gaviria et al. describe relevant novel insights into their common features, including RNA binding properties, unstructured domains, and interplay with other proteins important to RNA metabolism.

This work was supported by the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement #101038064 (Widening Fellowship), the National Science Centre 2020/39/D/NZ1/01651 (SONATA) together with EEA & Norway Grants 2020/37/K/NZ1/02312 (POLS) to Katarzyna Bandyra.